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KMID : 0043319960190040261
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Archives of Pharmacal Research
1996 Volume.19 No. 4 p.261 ~ p.263
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In Vitro Chemosensitivity Test of SK-302B on Human Colon Carcinoma Cell Lines
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Kim Soo-Kie
Ahn Chan-Mug
Kim Tae-Ue
Choi Sun-Ju
Park Yoon-Sun
Shin Woon-Seob
Koh Choon-Myung
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Abstract
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SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C/sub 50/H/sub 66/N/sub 11/S/sub 2/). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.
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KEYWORD
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SK-302B, Colon cancer cell line, Chemosensitivity
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